6-HYDROXYDOPAMINE HYDROBROMIDE
- Product Name
- 6-HYDROXYDOPAMINE HYDROBROMIDE
- CAS No.
- 636-00-0
- Chemical Name
- 6-HYDROXYDOPAMINE HYDROBROMIDE
- Synonyms
- Oxidopamine HBr;6-HYDROXYDOPAMINE HBR;6-OHDA (hydrobromide);6-Hydroxydopamine hydrbromide;2,4,5-Trihydroxyphenethylamine;6-HYDROXYDOPAMINE HYDROBROMIDE;KEMPTIDE, SYNTHETIC, >97% PURITY;Oxidopamine (6-OHDA) hydrobromide;2,5-DIHYDROXYTYRAMINE HYDROBROMIDE;6-HYDROXYDOPAMINE HYDROBROMIDE 99%
- CBNumber
- CB2288961
- Molecular Formula
- C8H12BrNO3
- Formula Weight
- 250.09
- MOL File
- 636-00-0.mol
6-HYDROXYDOPAMINE HYDROBROMIDE Property
- Melting point:
- 216-220 °C(lit.)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- solid
- color
- tan to brown
- BRN
- 3713280
- Stability:
- Hygroscopic, Light Sensitive
- InChIKey
- MLACDGUOKDOLGC-UHFFFAOYSA-N
- CAS DataBase Reference
- 636-00-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 162957
- Product name
- 6-Hydroxydopamine hydrobromide
- Purity
- 95%
- Packaging
- 1g
- Price
- $479
- Updated
- 2024/03/01
- Product number
- 162957
- Product name
- 6-Hydroxydopamine hydrobromide
- Purity
- 95%
- Packaging
- 5g
- Price
- $1146
- Updated
- 2024/03/01
- Product number
- 25330
- Product name
- 6-OHDA (hydrobromide)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 162957
- Product name
- 6-Hydroxydopamine hydrobromide
- Purity
- 95%
- Packaging
- 50mg
- Price
- $41.5
- Updated
- 2024/03/01
- Product number
- 162957
- Product name
- 6-Hydroxydopamine hydrobromide
- Purity
- 95%
- Packaging
- 250mg
- Price
- $147
- Updated
- 2024/03/01
6-HYDROXYDOPAMINE HYDROBROMIDE Chemical Properties,Usage,Production
Description
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.
Chemical Properties
beige to brown crystalline powder
Uses
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
General Description
Solutions should be freshly prepared and protected from exposure to light.
Biochem/physiol Actions
Neurotoxin that destroys catecholaminergic terminals.
storage
-20°C
6-HYDROXYDOPAMINE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
6-HYDROXYDOPAMINE HYDROBROMIDE Suppliers
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View Lastest Price from 6-HYDROXYDOPAMINE HYDROBROMIDE manufacturers
- Product
- 6-HYDROXYDOPAMINE HYDROBROMIDE 636-00-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-18
- Product
- 6-HYDROXYDOPAMINE HYDROBROMIDE 636-00-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24